Improvement of Naturally Aged Skin with Vitamin A (Retinol)

Study Objective: To evaluate the effectiveness of topical retinol (vitamin A) in improving the clinical signs of naturally aged skin.

Results of the Study: After 24 weeks, an intent-to-treat analysis using the last-observation-carried-forward method revealed that there were significant differences between retinol-treated and vehicle-treated skin for changes in fine wrinkling scores. As measured in a subgroup, retinol treatment significantly increased glycosaminoglycan expression and procollagen I immunostaining compared with vehicle.

Conclusions: Topical retinol improves fine wrinkles associated with natural aging. Significant induction of glycosaminoglycan, which is known to retain substantial water, and increased collagen production are most likely responsible for wrinkle effacement. With greater skin matrix synthesis, retinol-treated aged skin is more likely to withstand skin injury and ulcer formation along with improved appearance.

Published in Arch Dermatol (2007)

Topical retinol improves fine wrinkles associated with natural aging.

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